Publicaties
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CXCR4-using HIV type 1 variants are more commonly found in peripheral blood mononuclear cell DNA than in plasma RNA Universiteit Gent
Objective: To compare the distribution of R5-like and X4-like HIV-1 envelope sequences in plasma and peripheral blood mononuclear cell (PBMC). Methods: Clonal sequencing of the HIV-1 glycoprotein 120 region was performed on PBMC DNA and plasma RNA of 11 HIV-1 subtype B-infected patients with high probability of carrying X4 virus. Coreceptor use was predicted using the position-specific scoring matrix (PSSM). Results: A total of 330 and 427 ...
Defining a Total HIV DNA threshold as guidance for therapy simplification strategies Universiteit Gent
HIV DNA as a predictive marker for virological failure of darunavir/r monotherapy : a substudy of the PROTEA trial to define a cut-off for succes Universiteit Gent
Cobalt Oxide Porous Nanocubes-Based Electrochemical Immunobiosensing of Hepatitis B Virus DNA in Blood Serum and Urine Samples KU Leuven
In this work, we report a new biosensing platform for hepatitis B virus (HBV) DNA genosensing using cobalt oxide (Co3O4) nanostructures. The tunable morphologies of Co3O4 nanostructures such as porous nanocubes (PNCs), nanooctahedra (NOHs), and nanosticks (NSKs) are synthesized, and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) patterns, nitrogen adsorption/desorption ...
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture KU Leuven
Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, ...
Viral DNA polymerase inhibitors KU Leuven
© Springer Science+Business Media, LLC 2009. All rights reserved. DNA viruses, as well as their host cells, require a DNA-dependent DNA polymerase to faithfully replicate their genomes. Viruses with small DNA genomes, such as papillomaviruses and polyomaviruses, have a limited coding capacity and utilize mainly the host replication machinery for their genome amplification. In contrast, large DNA viruses encode a specific polymerase equipped with ...
Third generation sequencing and herpesvirus diversity: Towards complete double-stranded DNA virus genomes KU Leuven
Viral variability can be understood as genetic differences between nucleotide sequences. It can be used to define viral taxonomic units (species, genera, class, or family), viral subgroups, strains or life-cycle stages (lytic and latent phases). Viral diversity has been extensively studied, mostly through second-generation sequencing techniques, such as IonTorrent or Illumina sequencing. In the last years, third-generation technologies, such as ...
Outcome in Caucasian patients with hepatitis B e antigen negative chronic infection: A long-term observational cohort study Universiteit Hasselt KU Leuven
Sensitive polymerase chain reaction assays to measure hepatitis B virus (HBV) DNA became only available the last decade. Hence, the long-term outcome of Caucasian patients in Western Europe with hepatitis B e antigen (HBeAg)-negative chronic infection, especially with a baseline HBV DNA level > 2000 IU/mL, is still unclear. Out of a cohort of 1936 chronic HBV patients, 413 Caucasian individuals were identified with HBeAg-negative chronic ...
High prevalence of active and occult hepatitis B virus infections in healthcare workers from two provinces of South Africa Universiteit Antwerpen
Background Hepatitis B (HB) is a vaccine-preventable liver disease caused by infection with the blood-borne hepatitis B virus (HBV). South African healthcare workers (HCWs) may be at high risk of occupational exposure to HBV infection, since previous studies have found suboptimal levels of protection against HBV in HCWs. Methods A descriptive prevalence study based on self-administered questionnaires with data on demographics and HB vaccination ...