Cellular, molecular and functional characterization of quiescence in Leishmania donovani, the etiological agent of visceral leishmaniasis Instituut voor Tropische Geneeskunde
Jean-Claude Dujardin, JC Dujardin
Quiescence is a survival strategy adopted by several pathogens in response to prolonged periods of stress, such as drug treatment or host’s immune response. It is characterized by an overall downregulated metabolism, decreased biosynthetic capability and lower level of energy together with a slow or no proliferation. Quiescence of pathogens can represent a major health implication, as it renders them less susceptible to chemotherapy and allows ...