Coӧrdinatie van de celcyclus en DNA-foutenherstel via de eiwitfosfatase-1-regulator NIPP1. KU Leuven
NIPP1 is an inhibitor of protein phosphatase-1 (PP1) and controls key signaling pathways of cell proliferation, DNA-damage signalling and oncogenesis. With this research project we propose to explore the molecular basis of NIPP1 functions. Using newly developed mouse models and cell-based tools we will examine whether the established NIPP1 functions are all mediated by associated PP1. We will also investigate whether NIPP1 is a DNA-damage ...