Publicaties
Performance on a multipathogen External Quality Assessment (EQA) panel by different mono- and multiplex nucleic acid amplification tests Universiteit Antwerpen
Molecular Methods in Food Safety Microbiology: Interpretation and Implications of Nucleic Acid Detection KU Leuven Universiteit Gent
Spherical Nucleic Acid enhanced FO-SPR DNA melting for detection of mutations in Legionella pneumophila KU Leuven
Detection of pathogen-specific antibodies by loop-mediated isothermal amplification Vrije Universiteit Brussel Universiteit Gent
Loop-mediated isothermal amplification (LAMP) is a method for enzymatically replicating DNA that has great utility for clinical diagnosis at the point of care (POC), given its high sensitivity, specificity, speed, and technical requirements (isothermal conditions). Here, we adapted LAMP for measuring protein analytes by creating a protein-DNA fusion (referred to here as a "LAMPole") that attaches oligonucleotides (LAMP templates) to IgG ...
Circulating cell-free nucleic acids and platelets as a liquid biopsy in the provision of personalized therapy for lung cancer patients Universiteit Antwerpen
Novel techniques and future directions in molecular diagnosis of malaria in resource-limited settings Instituut voor Tropische Geneeskunde KU Leuven Universiteit Antwerpen
Despite being preventable and treatable, malaria remains a global health concern with approximately 1.2 billion people at high risk of being infected, 90% of whom are in the resource-limited settings of sub-Saharan Africa. The continued decline in malaria cases globally has rekindled the possibility of elimination in certain regions. As humans constitute the main reservoir of malaria, prompt and accurate diagnosis by microscopy or rapid ...
Molecular-based isothermal tests for field diagnosis of malaria and their potential contribution to malaria elimination Instituut voor Tropische Geneeskunde KU Leuven Universiteit Antwerpen
In countries where malaria transmission has decreased substantially, thanks to the scale-up of control interventions, malaria elimination may be feasible. Nevertheless, this goal requires new strategies such as the active detection and treatment of infected individuals. As the detection threshold for the currently used diagnostic methods is 100 parasites/μL, most low-density, asymptomatic infections able to maintain transmission cannot be ...
Recent progress in molecular diagnosis of sleeping sickness Instituut voor Tropische Geneeskunde
Alternative sampling specimens for the molecular detection of mpox (formerly monkeypox) virus Instituut voor Tropische Geneeskunde KU Leuven
BACKGROUND: Mpox (formerly monkeypox) is a viral disease caused by the mpox virus (MPXV), endemic in Central and West Africa and currently causing a global outbreak of international concern. Much remains unknown about sample types most suited for mpox laboratory diagnosis. While it is established that high viral loads can be found in active skin lesions (currently the recommended mpox laboratory confirmation specimen type), WHO mpox testing ...