Publicaties
Partner perception of affective, behavioral, and cognitive reactions to voice use in people with Parkinson's disease Universiteit Gent
Diffusion alterations associated with Parkinson's disease symptomatology : a review of the literature Universiteit Gent
Treatments for progressing Parkinson's disease Vrije Universiteit Brussel
OBJECTIVE: A 'case scenario' study on clinical decisions in progressing Parkinson's disease (PD) was developed to complement scientific evidence with the collective judgment of a panel of experts.
METHODS: The opinions of 9 experts in movement disorders on the appropriateness of 9 common pharmacological treatments for 33 hypothetical patient profiles were compared to those of 14 general neurologists. Before rating the case scenarios, ...
Oxidative stress in genetic mouse models of Parkinson’s disease Vrije Universiteit Brussel
Risk of cardiac valve regurgitation with dopamine agonist use in Parkinson's disease and hyperprolactinaemia: a multi-country, nested case-control study. Vrije Universiteit Brussel
The Proteasome Inhibition Model of Parkinson's disease Vrije Universiteit Brussel
The pathological hallmarks of Parkinson's disease are the progressive loss of nigral dopaminergic neurons and the formation of intracellular inclusion bodies, termed Lewy bodies, in surviving neurons. Accumulation of proteins in large insoluble cytoplasmic aggregates has been proposed to result, partly, from a failure in the function of intracellular protein degradation pathways. Evidence in support for such a hypothesis emerged in the ...
The risk of new onset heart failure associated with dopamine agonist use in Parkinson's disease. Vrije Universiteit Brussel
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease Vrije Universiteit Brussel Universiteit Antwerpen
High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common Omi/HtrA2 variants in the Genetic Epidemiology of Parkinson's disease (GEO-PD) consortium. GEO-PD sites provided clinical and genetic data including affection status, gender, ethnicity, age at study, age at examination (all ...
Mutations in glucocerebrosidase are a major genetic risk factor for Parkinson's disease and increase susceptibility to dementia in a Flanders-Belgian cohort Vrije Universiteit Brussel Universiteit Antwerpen
OBJECTIVE: To investigate the frequency of glucocerebrosidase (GBA) mutations in a Flanders-Belgian Parkinson's disease (PD) patient cohort and to assess genotype-phenotype correlations.
METHODS: We performed an in-depth sequencing of all coding exons of GBA in 266 clinically well-characterized PD patients and 536 healthy control individuals.
RESULTS: We identified rare, heterozygous GBA mutations in 12 PD patients (4.5%) and in 2 ...