Structure, Dynamics, and Kinetics of Weak Protein–Protein Complexes from NMR Spin Relaxation Measurements of Titrated Solutions Vrije Universiteit Brussel
Almost all cellular mechanisms are controlled by protein-protein interactions, and the dynamic and kinetic properties of these interactions determine cellular function. Weak or transient protein-protein interactions, with equilibrium dissociation constants approaching millimolar ranges, are known to control numerous biological processes, including transcription, replication, and signal transduction. NMR spectroscopy is an essential tool for the ...