Publicaties

The development of the philosophy of science in the 20th century has created a framework where issues concerning funding dynamics can be easily accommodated. It combines the historical-philosophical approach of Thomas Kuhn (1962) with the sociological approach of Robert K. Merton (1973), linking the ‘exact’ sciences to economy and politics. Out of this came a new domain, namely the study of scientific practices (Pickering, 1992). In this article ...

Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells ...

Two consecutive series of hip arthroplasties with closely similar anatomic uncemented femoral implants [207 Profile (DePuy) and 171 Image (Smith&Nephew) stems] were compared with regard to postoperative femoral fractures. All arthroplasties were performed by senior staff surgeons, mainly on patients below 65 years of age. In the Image group the occurrence rate of postoperative periprosthetic femoral fractures was higher (9.36%) compared to ...

Two different kinds of experimental approaches yielding three-dimensional structural information on metastable semi-coherent precipitates are demonstrated. By combining high-resolution images from two independent viewing directions a full description of the strain field surrounding a nano-sized Ni4Ti3 precipitate in Ni-Ti can be obtained. The principal axes and strains correlate well with the transformation strain of the observed R-phase ...

We are increasingly exposed to complex societal and technological problems. Qualified Science, Technology, Engineering and Mathematics (STEM) professionals are needed to solve these problems and cope with contemporary demands such as sustainable energy and efficient healthcare [1]. It is not surprising then that the World Economic Forum's Future of Jobs Report (2016) predicted a job gain in STEM fields for the following years [2]. However, we do ...

© 1998-2012 IEEE. The Need for STEM Professionals We are increasingly exposed to complex societal and technological problems. Qualified Science, Technology, Engineering and Mathematics (STEM) professionals are needed to solve these problems and cope with contemporary demands such as sustainable energy and efficient healthcare [1]. It is not surprising then that the World Economic Forum's Future of Jobs Report (2016) predicted a job gain in STEM ...

OBJECTIVE:
To study the ability of human spermatogonial stem cells (hSSCs) to proliferate in vitro under mouse spermatogonial stem cells (mSSCs) culture conditions.
DESIGN:
Experimental basic science study.
SETTING:
Reproductive biology laboratory.
PATIENT(S):
Cryopreserved testicular tissue with normal spermatogenesis obtained from three donors subjected to orchiectomy due to a prostate cancer treatment.
...

Mesenchymal stromal cells (MSCs) are multipotent stem cells with immunosuppressive and trophic support functions. While MSCs from different sources frequently display a similar appearance in culture, they often show differences in their surface marker and gene expression profiles. Although bone marrow is considered the ‘‘gold standard’’ tissue to isolate classical MSCs (BM-MSC), MSC-like cells are currently also derived from more easily ...