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Human spermatogonial stem cells display limited proliferation in vitro under mouse spermatogonial stem cell culture conditions. Vrije Universiteit Brussel
OBJECTIVE:
To study the ability of human spermatogonial stem cells (hSSCs) to proliferate in vitro under mouse spermatogonial stem cells (mSSCs) culture conditions.
DESIGN:
Experimental basic science study.
SETTING:
Reproductive biology laboratory.
PATIENT(S):
Cryopreserved testicular tissue with normal spermatogenesis obtained from three donors subjected to orchiectomy due to a prostate cancer ...
To study the ability of human spermatogonial stem cells (hSSCs) to proliferate in vitro under mouse spermatogonial stem cells (mSSCs) culture conditions.
DESIGN:
Experimental basic science study.
SETTING:
Reproductive biology laboratory.
PATIENT(S):
Cryopreserved testicular tissue with normal spermatogenesis obtained from three donors subjected to orchiectomy due to a prostate cancer ...
Stem cells in the pituitary gland and candidate cancer stem cells in pituitary tumors KU Leuven
It has repeatedly been postulated that the pituitary gland contains stem cells, putatively involved in the generation of new hormonal cells during homeostatic turnover as well as during plastic remodelling in response to changing endocrine needs of the body. In previous studies, our group clearly designated a candidate stem cell population in the anterior pituitary (AP) lobe of the adult mouse using the side population (SP) approach. In the ...
Spermatogonial stem cells. An update on spermatogonial stem cell banking and transplantation Vrije Universiteit Brussel
Like every other adult stem cell in the human body, spermatogonial stem cells (SSCs) have the capacity to either renew themselves or to start differentiation, i.e. spermatogenesis. Due to these properties, several options for preservation and re-establishment of the spermatogenic process exist.
Prevention of sterility has become an important issue in reproductive medicine. For adult men, sterility after cancer treatment can be ...
Prevention of sterility has become an important issue in reproductive medicine. For adult men, sterility after cancer treatment can be ...
Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function KU Leuven
© 2017, Mary Ann Liebert, Inc. During ontogeny, fetal liver (FL) acts as a major site for hematopoietic stem cell (HSC) maturation and expansion, whereas HSCs in the adult bone marrow (ABM) are largely quiescent. HSCs in the FL possess faster repopulation capacity as compared with ABM HSCs. However, the molecular mechanism regulating the greater self-renewal potential of FL HSCs has not yet extensively been assessed. Recently, we published RNA ...
Stem Cell Technology in Cardiac Regeneration: A Pluripotent Stem Cell Promise KU Leuven
Despite advances in cardiovascular biology and medical therapy, heart disorders are the leading cause of death worldwide. Cell-based regenerative therapies become a promising treatment for patients affected by heart failure, but also underline the need for reproducible results in preclinical and clinical studies for safety and efficacy. Enthusiasm has been tempered by poor engraftment, survival and differentiation of the injected adult stem ...
Single-cell PCR analysis of murine embryonic stem cells cultured on different substrates highlights heterogeneous expression of stem cell markers KU Leuven
BACKGROUND INFORMATION: In the last few years, recent evidence has revealed that inside an apparently homogeneous cell population there indeed appears to be heterogeneity. This is particularly true for embryonic stem (ES) cells where markers of pluripotency are dynamically expressed within the single cells. In this work, we have designed and tested a new set of primers for multiplex PCR detection of pluripotency markers expression, and have ...
Canine adipose-derived-mesenchymal stem cells do not lose stem features after a long-term cryopreservation KU Leuven
Adult stem cells are nowadays used for treating several pathologies. A putative stem cell population was found in the adipose tissue of mammals and canine adipose tissue-derived-mesenchymal stem cells (cA-MSC) have been shown to possess the capacity to differentiate into several lineages. The main goal of our research was to fully characterize cA-MSC and examine the effects of cryopreservation on their stemness features. Each sample of cA-MSC ...
In vitro osteoblastic differentiation of human mesenchymal stem cells and human dental pulp stem cells on poly-L-lysine-treated titanium-6-aluminium-4-vanadium KU Leuven
Three-dimensional (3D) titanium-6-aluminium-4-vanadium (Ti6Al4V) is a widely used biomaterial for orthopedic prosthesis and dental implants; thanks to its very high-mechanical strength and resistance to corrosion. Human mesenchymal stem cells (hMSCs) and dental pulp stem cells (hDPSCs) are responsible for bone regeneration following colonization of prosthesis or dental implants. Both hMSCs and hDPSCs have lower ability to colonize this ...
Allogeneic stem cell transplantation as salvage therapy in patients with diffuse large B-cell non-Hodgkin's lymphoma relapsing after an autologous stem cell transplantation. An analysis of the EBMT Registry KU Leuven
PURPOSE: To analyze the outcome, including nonrelapse mortality (NRM), relapse rate (RR), progression-free survival (PFS), and overall survival (OS), of patients with diffuse large B-cell non-Hodgkin's lymphoma (DLBCL) relapsed after an autologous stem-cell transplantation (ASCT) and treated with an allogeneic stem-cell transplantation (allo-SCT). PATIENTS AND METHODS: The European Group for Blood and Marrow Transplantation database was scanned ...