European view on the immunopathology of nasal polyposis: first results of the GA²LEN sinusitis cohort study Universiteit Gent
Introduction and aim: Chronic rhinosinusitis with nasal polyposis is in Caucasians hallmarked by a Th-2-linked eosinophilic inflammation with polyclonal IgE production. Although evidence for a disease-modifying role of IgE specific to Staphylococcal enterotoxins (SAE-IgE) is well established, there have been variable reports on their prevalence in nasal polyp patients. We aimed to characterize the epidemiology of SAE-IgE-positivity and its ...