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Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth Vlaams Instituut voor Biotechnologie KU Leuven
Histone Deacetylase 6 (HDAC6) as therapeutic target in axonal Charcot-Marie-Tooth disease KU Leuven
Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system, affecting 1 in 2500 people. Progressive degeneration of the motor nerves leads to the development of motor problems such as muscle wasting and weakness, steppage gate and deformities of hand and feet. Also the sensory nerves are affected leading to reduced sensation of touch, pain and temperature. When only motor axons are affected, the ...
Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease KU Leuven
Charcot-Marie-Tooth (CMT) disease is a disorder of the peripheral nervous system where progressive degeneration of motor and sensory nerves leads to motor problems and sensory loss and for which no pharmacological treatment is available. Recently, it has been shown in a model for the axonal form of CMT that histone deacetylase 6 (HDAC6) can serve as a target for the development of a pharmacological therapy. Therefore, we aimed at developing new ...
Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome Vlaams Instituut voor Biotechnologie KU Leuven
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6 KU Leuven
TDP-43 is an RNA/DNA-binding protein implicated in transcriptional repression and mRNA processing. Inclusions of TDP-43 are hallmarks of frontotemporal dementia and amyotrophic lateral sclerosis. Besides aggregation of TDP-43, loss of nuclear localization is observed in disease. To identify relevant targets of TDP-43, we performed expression profiling. Thereby, histone deacetylase 6 (HDAC6) downregulation was discovered on TDP-43 silencing and ...
INHIBITION OF HISTONE DEACETYTASE 6 (HDAC6) AS A THERAPEUTIC STRATEGY IN CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHIES KU Leuven
As cancer is becoming more and more a chronic disease, a large proportion of patients is confronted with devastating side effects of certain anti-cancer drugs. The most common neurological complications are painful peripheral neuropathies. Chemotherapeutics that interfere with microtubules, including plant-derived vinca-alkaloids such as vincristine, can cause these chemotherapy-induced peripheral neuropathies (CIPN). Available treatments focus ...