Design and development of a new vector platform for CXCR4-targeted molecular imaging and radionuclide therapy KU Leuven
The CXC chemokine receptor 4 (CXCR4) is a well-described G protein-coupled receptor (GCPR) that is involved in different physio-pathological processes upon binding of its endogenous ligand CXC chemokine 12 (CXCL12). CXCR4 is expressed throughout development and adulthood on a variety of cell types including lymphocytes, endothelial, epithelial and hematopoietic stem cells (HSCs). CXCR4 plays a fundamental physiological role in hematopoiesis, ...