Organisation
Laboratory of Biosignaling & Therapeutics
Division
The Laboratory of Biosignaling & Therapeutics investigate cellular signal transduction pathways at the molecular level. One of our major goals is to identify and develop novel biomarkers or therapeutic targets for human diseases. The current focus is on the (mis)regulation of chromatin signaling, DNA repair and cell division in cancer cells by enzymes known as protein phosphatases.
Current researchers
1 - 10 of 11 results
- Mathieu Bollen (Responsible)
- Joao Barbosa (Member)
- Monique Beullens (Member)
- Mathieu Bollen (Member)
- Xinyu Cao (Member)
- Zander Claes (Member)
- Monica Dos Santos Ferreira (Member)
- Marloes Jonkhout (Member)
- Sarah Lemaire (Member)
- Aleyde Van Eynde (Member)
Projects
1 - 10 of 41
- Phospho-regulation at the crossroads of cell proliferation and DNA-damage controlFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Coordination of cell-cycle progression and DNA-damage repair by the protein phosphatase-1 regulator NIPP1From1 Mar 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Life-course regulators of protein phosphatase-1From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Host cell phosphatases in the life cycle of DNA virusesFrom1 Oct 2020 → TodayFunding: BOF - projects
- Dual function of SDS22 in the biogenesis of protein phosphatase-1 holoenzymesFrom14 Oct 2019 → 14 Oct 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of histone modifications in the life cycle of AAV2 and recombinant AAV-mediated transgene expressionFrom1 Oct 2019 → 27 Jan 2023Funding: FWO Strategic Basic Research Grant, BOF - doctoral mandates
- Chaperone-mediated biogenesis and activity regulation of protein phosphatase-1From3 Sep 2019 → 10 Jan 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular timers of the spindle assembly checkpointFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
Publications
21 - 30 of 135
- Structure and Function of the Two Tandem WW Domains of the Pre-mRNA Splicing Factor FBP21 (Formin-binding Protein 21)(2009)
Authors: Monique Beullens, Emilia Nicolaescu, Bart Lesage, Mathieu Bollen
Pages: 25375 - 25387 - Testing for recombinant erythropoietin(2008)
Authors: Mathieu Bollen, Monique Beullens
Pages: 237 - 241 - Glycemic penalty index for adequately assessing and comparing different blood glucose control algorithms(2008)
Authors: Tom Van Herpe, Joseph De Brabanter, Monique Beullens, Bart De Moor, Greet Van den Berghe
- Kinetochore Signalling: The KIss that MELTs Knl1(2014)
Authors: Mathieu Bollen
Pages: R68 - R70 - TXRF analysis of native PP1 and the PP1-Inhibitor 2 complex(2014)
Authors: Ewald Heroes, Jens Rip, Luc Van Meervelt, Stefan De Gendt, Monique Beullens, Mathieu Bollen
Pages: S850 - S851 - DNA methylation-guided prediction of clinical failure in high-risk prostate cancer(2015)
Authors: Aleyde Van Eynde, Steven Joniau, Evelyne Lerut, Annouschka Laenen, Thomas Gevaert, Olivier Gevaert, Karin Haustermans, Mathieu Bollen
Pages: 1 - 13 - The protein phosphatase 1 regulator NIPP1 is essential for mammalian spermatogenesis(2017)
Authors: Shannah Boens, Claudia Winkler, Kathelijne Szekér, Iris Verbinnen, Aleyde Van Eynde, Mathieu Bollen
- The deletion of the phosphatase regulator NIPP1 causes progenitor cell expansion in the adult liver(2016)
Authors: Shannah Boens, Iris Verbinnen, Kathelijne Szekér, Thomas Gevaert, Myriam Baes, Tania Roskams, Aleyde Van Eynde, Mathieu Bollen
Pages: 2256 - 2262 - Physicians' attitudes and knowledge concerning antibiotic prescription and resistance: questionnaire development and reliability(2016)
Authors: Monica Dos Santos Ferreira
- Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells (Retraction of Vol 288, Pg 24200, 2013)(2017)
Authors: Cenk Kig, Monique Beullens, Lijs Beke, Aleyde Van Eynde, Johannes T Linders, Dirk Brehmer, Mathieu Bollen
Pages: 12786 - 12786