Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Current researchers
11 - 20 of 21 results
- Eren Can Eksi (Member)
- Nikolai Hecker (Member)
- Jasper Janssens (Member)
- Niklas Kempynck (Member)
- Vasilis Konstantakos (Member)
- David Mauduit (Member)
- Alexandra Pančíková (Member)
- Gabriele Partel (Member)
- Olga Sigalova (Member)
- Ibrahim Ihsan Taskiran (Member)
Projects
11 - 20 of 64
- A whole-organism approach to uncover gene regulatory mechanisms in Drosophila melanogaster: towards a regulatory map at single-cell resolutionFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Mapping gene regulatory networks in the era of single-cell multi-omicsFrom1 Sep 2022 → TodayFunding: BOF - doctoral mandates
- Modeling gene regulation through end-to-end deep learning for expression predictionFrom1 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of long read genome sequencing and single-cell multi-omics to identify genetic variation underlying Parkinson’s diseaseFrom1 Sep 2022 → TodayFunding: BOF - doctoral mandates
- Rebus EsperFrom29 Jun 2022 → TodayFunding: Other federal scientific institutions
- Advanced infrastructure for fabrication of next-generation micro- and nanosystemsFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Cell-cell cOmmuNicaTion As a driver of Cancer cell state identiTy - Decoding the impact of cell-cell communications on the identity of tumor states in skin cancersFrom1 Jan 2022 → TodayFunding: FWO EOS
- Unravelling the regulatory code orchestrating neural circuit formationFrom5 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Deciphering the evolution of gene regulatory networks and enhancer architectures in neuronal cell types using single-cell deep learning and comparative genomicsFrom1 Oct 2021 → TodayFunding: FWO senior postdoctoral fellowship
- OncoAI - a machine-learning framework to predict cancer cell vulnerability at the gene-regulatory levelFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
Publications
1 - 10 of 177
- HIGH-THROUGHPUT SEQUENCING OF THE HUMAN HEPATIC PROGENITOR CELL NICHE REVEALS DIFFERENT SIGNALLING PATHWAYS DEPENDING ON THE UNDERLYING CHRONIC LIVER DISEASE(2015)
Authors: Olivier Govaere, Jasper Wouters, Wouter Van Delm, R van Eijsden, An Ceulemans, Werner Van Steenbergen, Diethard Monbaliu, Frederik Nevens, Tania Roskams
Pages: S239 - S239 - Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer(2015)
Authors: Hana Imrichova
Pages: 1814 - 1830 - The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene(2016)
Authors: Jasper Wouters, Joost van den Oord
- Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma(2020)
Authors: Jasper Wouters, Joost van den Oord
- Cancer stem cells in cutaneous melanoma(2009)
Authors: Jasper Wouters, Joost van den Oord, Hugo Vankelecom
Pages: 225 - 235 - Evidence for DNA-Binding Domain-Ligand-Binding Domain Communications in the Androgen Receptor(2012)
Authors: Christine Helsen, Vanessa Dubois, Annelien Verfaillie, Marc De Maeyer, Frank Claessens
Pages: 3033 - 3043 - CD45 antigen negativity in T-lineage ALL correlates with PTPRC mutation and sensitivity to a selective JAK inhibitor(2015)
Authors: Stein Aerts, Ellen Geerdens, Jan Cools
Pages: 884 - 7 - Plasma cells in primary melanoma. Prognostic significance and possible role of IgA(2016)
Authors: Francesca Bosisio, Jasper Wouters, Marguerite Stas, Joost van den Oord
Pages: 347 - 58 - BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis(2021)
Authors: Matteo Rossi, Chris Van den Haute, Maria Livia Sassano, Abhishek Garg, Francesca Bosisio, Jasper Wouters, Peter Vangheluwe, Wim Annaert, Johan Swinnen, Joost van den Oord, et al.
- A Functional In Situ Approach to TILs in Melanoma: A Critique on the Current Morphological Classification(2016)
Authors: Francesca Bosisio, Jasper Wouters, Nathalie Volders, Marguerite Stas, Joost van den Oord
Pages: 126A - 126A