Researcher
Kris Vleminckx
- Keywords:cancer research, rare diseases, CRISPR/Cas9, Developmental biology
- Disciplines:Cell signalling, Developmental genetics, Genome structure and regulation, Developmental biology, Vertebrate biology, Epigenetics, Genetics, Animal developmental and reproductive biology, Cancer biology
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Jan 2013 → 30 Sep 2018 - Department of Biomedical molecular biology (Department)
Member
From1 Jan 1999 → Today
Projects
11 - 20 of 30
- Elucidating the role of cis-regulation and of ultraconserved non-coding elements associated with the choroideremia gene CHMFrom1 Oct 2018 → 30 Sep 2022Funding: FWO fellowships
- Screening for drivers and dependency factors in a novel genetic model for T-ALL in Xenopus tropicalisFrom1 Oct 2018 → 31 Dec 2022Funding: FWO fellowships
- In vivo study of the function of RCBTB1, a novel disease gene for inherited retinal dystrophyFrom1 Jan 2018 → 31 Dec 2018Funding: FWO research grant KAN
- A novel CRISPR/Cas9-based workflow in Xenopus tropicalis to test
the pathogenicity of human missense variants implicated in
inherited blindnessFrom1 Jan 2018 → 30 Jun 2022Funding: FWO Strategic Basic Research Grant
- Identifiying targets for therapy in a novel genetic Xenopus model for desmoid tumor formation.From15 Jan 2016 → 14 Jan 2017Funding: Foreign foundations, funds with scientific view
- A novel genetically tractable model for Familial Adenomatous
Polyposis in XenopusFrom1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Identifying targets for therapy in a novel genetic Xenopus model for Familal Adenomatous PolyposisFrom1 Jan 2015 → 31 Dec 2018Funding: IWT personal funding - strategic basic research grants, IWT personal funding - specialisation scholarships
- Personalized functional genomics in Mendelian diseases: from DNA variants to clinical and bioethical implicationsFrom1 Jan 2015 → 30 Sep 2021Funding: BOF - Concerted Research Project from 1994
- A novel role for Wnt/β-catenin signaling in primordial germ cells during Xenopus developmentFrom1 Jan 2013 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Investigating the function of Wnt/β-catenin signaling in the rhombomeric boundariesFrom1 Oct 2012 → 30 Sep 2017Funding: BOF - Other initiatives, FWO fellowships
Publications
1 - 10 of 62
- Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis(2023)
Authors: Dieter Tulkens, Marthe Boelens, Thomas Naert, Marjolein Carron, Suzan Demuynck, Sylviane Dewaele, Gert Van Isterdael, David Creytens, Tim Pieters, Steven Goossens, et al.
Pages: 2404 - 2413 - Engraftment of allotransplanted tumor cells in adult rag2 mutant Xenopus tropicalis(2022)
Authors: Dieter Tulkens, Dionysia Dimitrakopoulou, Marthe Boelens, Tom Van Nieuwenhuysen, Suzan Demuynck, Wendy Toussaint, Pieter Van Vlierberghe, Kris Vleminckx
- CRISPR-SID : identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping(2021)
Authors: Thomas Naert, Dieter Tulkens, Tom Van Nieuwenhuysen, Joanna Przybyl, Suzan Demuynck, Matt van de Rijn, Mushriq Al-Jazrawe, Benjamin A. Alman, Paul Coucke, Kim De Leeneer, et al.
- RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis(2020)
Authors: Thomas Naert, Dionysia Dimitrakopoulou, Dieter Tulkens, Suzan Demuynck, Rivka Noelanders, Liza Eeckhout, Gert Van Isterdael, Dieter Deforce, Christian Vanhove, Kris Vleminckx
Pages: 2692 - 2706 - Modeling human hereditary cancer syndromes using CRISPR/Cas9 mediated genome editing in Xenopus tropicalis(2019)Volume: 27
Authors: D. Dimitrakopoulou, T. Naert, D. Tulkens, R. Noelanders, T. Van Nieuwenhuyse, Pieter Van Vlierberghe, Kris Vleminckx
Pages: 863 - 863 - Modeling human hereditary cancer syndromes using CRISPR/Cas9 mediated genome editing in Xenopus tropicalis(2019)Volume: 27
Authors: D. Dimitrakopoulou, T. Naert, D. Tulkens, R. Noelanders, T. Van Nieuwenhuyse, Pieter Van Vlierberghe, Kris Vleminckx
Pages: 475 - 475 - ΔN-Tp63 mediates Wnt/β-catenin-induced inhibition of differentiation in basal stem cells of mucociliary epithelia(2019)
Authors: Maximilian Haas, Jose Luis Gomez Vazquez, Dingyuan Iris Sun, Hong Tran Thi, Magdalena Brislinger, Alexia Tasca, Orr Shomroni, Kris Vleminckx, Peter Walentek
Pages: 3338 - 3352 - A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus(2019)
Authors: Jiejing Li, Mark Perfetto, Christopher Materna, Rebecca Li, Hong Tran Thi, Kris Vleminckx, Melinda K. Duncan, Shuo Wei
- Xenopus tropicalis : joining the armada in the fight against blood cancer(2019)
Authors: Dionysia Dimitrakopoulou, Dieter Tulkens, Pieter Van Vlierberghe, Kris Vleminckx
- CRISPR/Cas9-mediated knockout of Rb1 in Xenopus tropicalis(2018)Series: Methods in Molecular Biology
Authors: Thomas Naert, Kris Vleminckx, Pedro G Santiago-Cardona
Pages: 177 - 193