Projects
Agreement between self-reported and device-measured physical activity and sedentary behaviour in older adults with different levels of cognitive function – a multi-methodological approach KU Leuven
In view of the current ageing population, healthy ageing is a hot topic. Physical activity (PA) and sedentary behaviour (SB) are two modifiable lifestyle factors associated with healthy ageing. Much of the evidence on PA and SB is derived from epidemiological studies using PA/SB questionnaires. It is likely that non-pathological and pathological cognitive ageing affects the ability of older adults to complete these questionnaires, introducing ...
H-ferritin nanoparticle-mediated VHH/mAb delivery across the blood-brain barrier KU Leuven
Alzheimer's disease (AD) is the most common dementia in elders, but so far no effective treatments are available. BACE1 is the major β-secretase in vivo that initiates AD pathogenesis and considered as an attractive drug target. Nevertheless, the development of BACE1 inhibitors has proved to be extremely challenging due to their low selectivity and limited penetration of blood-brain barrier (BBB). Monoclonal antibody (mAb) and single domain ...
NeuroFerro. University of Antwerp
Deciphering the microglia-neuron interactions in human Alzheimer's disease. University of Antwerp
NEURONET - Phase III Hasselt University
Translational investigation of the role of Hsp90 in neurodegenerative proteinopathies using positron emission tomography (PET) KU Leuven
Heat Shock protein-90 (Hsp90) is an ubiquitous "chaperone" protein responsible for (re)folding of client proteins to prevent them from degradation. Hsp90 is expressed at high levels in brain and recent research suggests a role of Hsp90 in neurodegenerative diseases. Positron emission tomography (PET) is a molecular imaging technique that allows in vivo quantification of the body distribution of radioactive tracers. We recently developed PET ...
VIB Grant for Van Den Bosch Lab_Period:2022-01-01-2026-12-31 Flanders Institute for Biotechnology
Gerodent PLUS: primary oral care for home-dwelling elderly Ghent University
The aim of Gerodent PLUS is to promote good oral health and to create the currently absent continuity in the provision of oral care for the rapidly growing group of vulnerable elderly living at home at the level of primary care regions.This goal is pursued through (1) improved interprofessional collaboration between caregivers and (2) improving access to care for frail and care-dependent elderly people who stay at home or in a form of ...