Shining new light on G protein-coupled receptors by combining of a new class of sensors with tailored high-resolution fluorescence microscopy. KU Leuven
G protein-coupled receptors (GPCRs) are the ears and eyes of the cell. Encoded by more than 800 genes on the human genome and target for more than 30% of the marketed drugs, they sense extracellular information and translate it to intracellular action. The vast importance of these receptor molecules has resulted into a wealth of information on how they work and communicate with the cellular machinery. However, while new insights emerge on ...