The Cu(OTf)2 catalysed microwave assisted synthesis of a new scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one

Korte inhoud:The synthesis of novel 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-ones is described including a one-step Mannich-type reaction followed by intramolecular ring closure of ethyl 3-methylpyridazine-4- carboxylate and aldimines, catalysed by the Lewis acid Cu(OTf)2 under microwave heating. This synthesis opens up possibilities to access this unexplored scaffold for medicinal chemistry.

Jaar van publicatie:2014

Trefwoorden:Organische en medische scheikunde

BOF-keylabel:ja

IOF-keylabel:ja

CSS-citation score:1

Auteurs:National

Authors from:Higher Education

Toegankelijkheid:Open