Lysosomes and Mitophagy

Korte inhoud:© 2016 John Wiley & Sons, Inc. All rights reserved. Mitophagy is the selective elimination of dysfunctional or unwanted mitochondria, by lysosomes, during periods of stress or during regulated development. Since the initial discovery of mitochondria in the 19th century, accumulating evidence continues to reshape our views of mitochondrial functions and their vital role in managing various cellular processes such as metabolic homeostasis, energy production, stress response, and cell death. In 2005, J.J. Lemasters proposed the term "mitophagy" based on similarities to the peroxisomal autophagy (pexophagy), suggesting the selective removal of cytoplasmic organelles by autophagy. An important observation that precedes mitophagy is mitochondrial fragmentation, a process that may in part also overlap with the production of mitochondrial vesicles destined for degradation. Autophagy can be divided into two major steps: induction of the general autophagic machinery, and priming of targeted mitochondria for autophagic recognition and degradation. The chapter also discusses mitophagy in yeast and mammals.

ISBN:9781118978320

Jaar van publicatie:2016