Octrooien

The invention relates to antigen-binding protein agents specifically binding the hemagglutinin- neuraminidase (HN) protein of human parainfluenza virus 3 (hPIV-3), with cross-reactivity for Sendai Virus (SeV) as well as human parainfluenza virus serotype 1 (hPIV-1) HN, resulting in a cross-neutralizing binding protein to act as a protection agent against parainfluenza infection and/or disease caused by such an infection. More specifically, the invention relates to a family of immunoglobulin single variable domains (ISVDs) capable of broadly blocking HN neuraminidase activity, thereby ...

A method and a system for processing a plurality of camera images of a human body surface target area over time, the method comprising the steps of obtaining a plurality of images of a human body surface target area of a human body captured by a first camera over time; obtaining physical data of said human body; and generating a 3D model of at least said human body surface target area.

A method and a system for processing a plurality of camera images of a human body target area over time, the method comprising the steps of obtaining a plurality of images of a human body target area of a human body captured by a first camera over time; obtaining physical data of said human body; and generating a 3D model of at least said human body target area.

The present invention relates to human CCR8 (hCCR8) binders, wherein the hCCR8 binder is cross-reactive with a non-human primate CCR8. Such binders are particularly useful for the depletion of intra-tumoural regulatory T-cells and immunotherapy in general.

A new type of liposomal formulation is developed for delivery of siRNA molecules into human skin. We call these liposomes "SECosomes" which stands for Surfactant - Ethanol - Cholesterol containing liposomes. DOTAP is used as cationic lipid and mixed with cholesterol and sodium cholate (=surfactant) in a 6:1:1 weight:weight:weight ratio. A hydroalcoholic with 70% Hepes Buffer and 30% ethanol is used as a solvent. The resulting SECosomes are positively charged, making them suitable for complexing negatively charged siRNA, through electrostatic interactions. In vitro characterization shows that ...

The present invention relates to a protective device (1) for protecting a proximal interphalangeal joint and a distal interphalangeal joint of a human finger. The device comprises a flexible sheath (3) for wearing around the human finger and at least four motion constraining elements (4) integrated in or secured to the flexible sheath (3). The motion constraining element (4) is adapted for constraining a lateral and/or rotational deviation motion of a first phalanx with respect to a second phalanx. The motion constraining element (4) covers a lateral side (L) of the flexible sheath (3) at a ...

The present invention relates to a protective device (1) for protecting a proximal interphalangeal joint and a distal interphalangeal joint of a human finger. The device comprises a flexible sheath (3) for wearing around the human finger and at least four motion constraining elements (4) integrated in or secured to the flexible sheath (3). The motion constraining element (4) is adapted for constraining a lateral and/or rotational deviation motion of a first phalanx with respect to a second phalanx. The motion constraining element (4) covers a lateral side (L) of the flexible sheath (3) at a ...

The invention relates to antigen-binding protein agents specifically binding the hemagglutinin-neuraminidase (HN) protein of human parainfluenza virus 3 (hPIV-3), with cross-reactivity for Sendai Virus (SeV) as well as human parainfluenza virus serotype 1 (hPIV-1) HN, resulting in a cross-neutralizing binding protein to act as a protection agent against parainfluenza infection and/or disease caused by such an infection. More specifically, the invention relates to a family of immunoglobulin single variable domains (ISVDs) capable of broadly blocking HN neuraminidase activity, thereby providing ...

The present invention relates to a protective device (1) for protecting a proximal interphalangeal joint and a distal interphalangeal joint of a human finger. The device comprises a flexible sheath (3) for wearing around the human finger and at least four motion constraining elements (4) integrated in or secured to the flexible sheath (3). The motion constraining element (4) is adapted for constraining a lateral and/or rotational deviation motion of a first phalanx with respect to a second phalanx. The motion constraining element (4) covers a lateral side (L) of the flexible sheath (3) at a ...

The invention in general relates to human hepatic 3D co-culture models, more in particular 3D spheroid co-cultures of human hepatocyte-like cells and hepatic stellate cells. Furthermore, the invention provides a method for obtaining such co-cultures, as well as the use of said co-cultures in the identification of pro-fibrotic and/or anti-fibrotic compounds.