Octrooien

The present invention provides a continuous flow process and system for the preparation of metal-carbene complexes, comprising the use of a continuous flow reactor containing a solid weak base, such as K2CO3, allowing to obtain highly pure metal carbene complexes in high yield, at short reaction times and at mild reaction conditions. In particular, the continuous flow process of the present invention comprises continuously passing a reaction medium comprising a salt of formula Z+-X-, such as an azolium salt, and a metal salt of formula MLn over a bed of a weak base, such as K2CO3 in a ...