Publicaties
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Wild Rats, Laboratory Rats, Pet Rats: Global Seoul Hantavirus Disease Revisited KU Leuven
Recent reports from Europe and the USA described Seoul orthohantavirus infection in pet rats and their breeders/owners, suggesting the potential emergence of a "new" public health problem. Wild and laboratory rat-induced Seoul infections have, however, been described since the early eighties, due to the omnipresence of the rodent reservoir, the brown rat Rattus norvegicus. Recent studies showed no fundamental differences between the ...
Estimation of the net influx rate Ki and the cerebral metabolic rate of glucose MRglc using a single static [¹⁸F]FDG PET scan in rats Universiteit Antwerpen
Since accurate quantification of 2-deoxy-2–18F-fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) requires dynamic acquisition with arterial input function, more practical semi-quantitative (static) approaches are often preferred. However, static standardized uptake values (SUV) are typically biased due to large variations in body weight (BW) occurring over time in animal studies. This study aims to improve static [18F]FDG PET SUV ...
Linking in vitro intrinsic dissolution rate and thermodynamic solubility with pharmacokinetic profiles of bedaquiline long-acting aqueous microsuspensions in rats Universiteit Gent
Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries Instituut voor Natuur- en Bosonderzoek
Simplified methods for estimating glomerular filtration rate in cats and for detection of cats with low or borderline glomerular filtration rate Universiteit Gent
Endurance-Type Exercise Increases Bulk and Individual Mitochondrial Protein Synthesis Rates in Rats Vrije Universiteit Brussel
Physical activity increases muscle protein synthesis rates. However, the impact of exercise on the coordinated up- and/or downregulation of individual protein synthesis rates in skeletal muscle tissue remains unclear. The authors assessed the impact of exercise on mixed muscle, myofibrillar, and mitochondrial protein synthesis rates as well as individual protein synthesis rates in vivo in rats. Adult Lewis rats either remained sedentary (n = ...
Investigating Association Between Behavior, Corticosterone, Heart Rate, and Blood Pressure in Rats Using Surrogate Marker Evaluation Methodology Universiteit Hasselt KU Leuven
The drug development process involves identifying a compound and assessing its merit through rigorous pre-clinical and clinical trials. The pre-clinical stage is designed to assess the chemical properties of the new drug, as well as to determine the steps for synthesis and purification. In this stage of drug development, circumstances might dictate the use of alternative endpoints than the originally anticipated clinically relevant endpoint. In ...
Strain and strain rate correctly identify myocardial dysfunction in advanced glycation end products (AGEs) injected rats Universiteit Hasselt
Purpose: Advanced glycation end products (AGEs) are known to play a key role in the development and progression of cardiovascular diseases, however, the precise underlying mechanism still remains elusive. The study was therefore established to identify the role of AGEs in the pathophysiology of heart failure. Methods: 13 Sprague-Dawley rats underwent a daily injection of 20 mg/kg BSA-modified AGEs (n=9) or control-BSA (n=4) for 6weeks. 2D echo ...