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Researcher
Johan Swinnen
- Disciplines:Other basic sciences not elsewhere classified
Affiliations
- Laboratory of Lipid Metabolism and Cancer (Division)
Responsible
From1 Jan 2012 → Today - Laboratory of Lipid Metabolism and Cancer (Division)
Member
From1 Jan 2012 → Today - Clinical and Experimental Endocrinology (Division)
Member
From1 Jan 2003 → 31 Dec 2011 - Department of Development and Regeneration (Department)
Member
From1 Oct 2000 → 31 Dec 2002
Infrastructure
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- An high-throughput automated small molecule screening platform
- Next Generation Magnetic Resonance Mass Spectrometry. (Consortium coordinator)
- KU Leuven Lipidomics Core Facility
- Multi-modal Coherent Raman Scattering (CRS) microscope with Stimulated Raman Scattering (SRS) and Coherent Anti-Stokes Raman Scattering (CARS) modalities
- 4D-Lipidomics: a new standard in advanced lipidomics research
Projects
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- Immunoglycolipidomics: Building a platform and pipeline of cancer therapiesFrom1 Jan 2026 → TodayFunding: IWT / VLAIO personal funding - innovation mandates
- Impact of Genetic Risk factors and Ageing on Neuronal organellar and lipid homeostasis in Parkinson and Alzheimer’s disease – GRAN’PAFrom1 Oct 2025 → TodayFunding: BOF - projects
- Aggressive salivary gland neoplasms: institutional-international collaborative evaluation of advances in clinical management and translational research into tumor biologyFrom22 Jan 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Enhancing Single-Cell Resolution in Mass Spectrometry Imaging through Advanced Sample PreparationFrom1 Jan 2025 → TodayFunding: BOF - scientific equipment program
- Lipid metabolism-directed crosstalk between microglia and neurons as driver of neurodegeneration in multiple sclerosis and Alzheimer’s disease.From1 Jan 2025 → TodayFunding: BOF - iBOF
- Enhancing Single-Cell Resolution in Mass Spectrometry Imaging through Advanced Sample PreparationFrom1 Jan 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Immunolipidomics: targeting lipid antigens to combat pancreatic cancerFrom1 Jan 2025 → TodayFunding: Foundations, funds and other with scientific goal
- PRORUST: Exploiting lipid metabolic vulnerabilities to trigger prostate tumor cell deathFrom1 Jan 2025 → TodayFunding: FWO research project (including WEAVE projects)
- Implementation of untargeted reverse phase lipidomics for deep lipidotypingFrom1 Dec 2024 → TodayFunding: BOF - research organisations
- Development and valorization of a cancer therapy based on a novel immunolipidomics platformFrom1 Oct 2024 → TodayFunding: IOF - technology validation in lab
Publications
1 - 10 of 149
- Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids(2025)Published in: Nature ProtocolsISSN: 1754-2189Issue: 10Volume: 20
- Best practices and tools in R and Python for statistical processing and visualization of lipidomics and metabolomics data(2025)Published in: Nature CommunicationsISSN: 2041-1723Issue: 1Volume: 16
- Altered Lipid Homeostasis in Mutant FUSR521H Astrocytes from HiPSCs(2025)Published in: Molecular NeurobiologyISSN: 0893-7648Issue: 9Volume: 62Pages: 11025 - 11029
- Lipid metabolism alterations in peripheral neuropathies(2025)Published in: NeuronISSN: 0896-6273Issue: 16Volume: 113Pages: 2556 - 2581
- Endoplasmic reticulum-mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis (vol 27, pg 902, 2025)(2025)Published in: Nature Cell BiologyISSN: 1465-7392
- Activated T cells break tumor immunosuppression by macrophage re-education.(2025)Published in: Cancer DiscoveryISSN: 2159-8274Issue: 7Volume: 15
- Glycosphingolipid synthesis is impaired in SLC35A2-CDG and improves with galactose supplementation(2025)Published in: Cellular and Molecular Life SciencesISSN: 1420-682XIssue: 1Volume: 82
- Early plasma ceramide and sphingomyelin levels reflect APOE genotype but not familial Alzheimer's disease gene mutations in female 5xFAD mice , with brain-region specific sphingolipid alterations(2025)Published in: Neurobiology of DiseaseISSN: 0969-9961Volume: 210
- Endoplasmic reticulum-mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis(2025)Published in: Nature Cell BiologyISSN: 1465-7392Issue: 6Volume: 27
- Complex Metabolomic Changes in a Combined Defect of Glycosylation and Oxidative Phosphorylation in a Patient with Pathogenic Variants in PGM1 and NDUFA13(2025)Published in: CellsISSN: 2073-4409Issue: 9Volume: 14
Linked dataset
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