Researcher
Stefaan De Smedt
- Keywords:drug delivery, biotherapeutics
- Disciplines:Nanobiotechnology, Environmental safety and health of nanotechnology, Nanoscale characterisation, Nanotechnology not elsewhere classified, Nanometrology, Other pharmaceutical sciences not elsewhere classified, In vitro testing, Biopharmaceuticals, Non-clinical studies, Biopharmaceutics, Pharmaceutical technology, Physical pharmacy, Vaccines, Nanomaterials, Nanomanufacturing, Nanofabrication, growth and self assembly, Nucleic acids, Gene and molecular therapy
Affiliations
- Board of Governors/Executive Board (Administrative office)
Member
From1 Oct 2014 → 30 Sep 2022 - Laboratories of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Laboratories of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Dean's Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Dean's Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Student Administration Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Student Administration Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Faculty of Pharmaceutical Sciences (Faculty)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Faculty of Pharmaceutical Sciences (Faculty)
Member
From1 Oct 2010 → 30 Sep 2014 - Department of Pharmaceutics (Department)
Member
From1 Oct 1996 → Today - Department of Pharmaceutical analysis (Department)
Member
From1 Oct 1992 → 30 Sep 1994
Infrastructure
1 - 1 of 1
- Confocal and two-photon Microscope (Consortium partner)
Projects
1 - 10 of 42
- A platform for the fast development of thermostable lyophilized mRNA lipid nanoparticle (LNP) vaccinesFrom7 Feb 2024 → TodayFunding: Foreign private sponsor - undefined
- LNP-DECODE: Deciphering the adjuvants activity of lipid nanoparticle-based mRNA vaccines in primary dendritic cellsFrom1 Jan 2024 → TodayFunding: BOF - projects
- Evaluation of formulation parameters o n the mRNA integrity within mRNA lipid nanoparticlesFrom20 Dec 2023 → TodayFunding: IOF - technology validation in lab
- ILM photodisruption: a biophotonic approach to promote retinal ganglion cell engraftment as a cure for blindnessFrom1 Nov 2023 → TodayFunding: FWO senior postdoctoral fellowship
- Immunopeptidomics-based Development of Next-Generation Bacterial mRNA VaccinesFrom1 Jul 2023 → TodayFunding: HORIZON.2.1 - Health
- Laser-induced nanobubbles for advanced therapies in the eye.From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Flow imaging microscope for advanced analysis of biopharmaceuticals and biological samplesFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Exploring and advancing mRNA lipid nanoparticles for the in situ generation of CAR-MsFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Mechanobiology control of immunogenic cell death by bio-polymers for cancer therapyFrom1 Oct 2022 → TodayFunding: BOF - projects
- Understanding and modulating the pro-inflammatory activity of lipid nanoparticles (LNP) in the COVID-19 mRNA vaccines: towards the development of more effective LNP formulations.From1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
Publications
41 - 50 of 73
- Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms(2018)
Authors: Eline Teirlinck, Ranhua Xiong, Toon Brans, Katrien Forier, Juan Fraire, Heleen Van Acker, Nele Matthijs, Riet De Rycke, Stefaan De Smedt, Tom Coenye, et al.
- Polyimide/cellulose acetate core/shell electrospun fibrous membranes for oil-water separation(2017)
Authors: Wenjing Ma, Zhongfu Guo, Juntao Zhao, Qian Yu, Fang Wang, Jingquan Han, Hui Pan, Jianfeng Yao, Qilu Zhang, Sangram Keshari Samal, et al.
Pages: 71 - 85 - The biocompatibility of nanosized materials: intracellular nanoparticle stability and effects on toxicity and particle functionality(2013)Volume: 8595
Authors: Stefaan Soenen, Stefaan De Smedt, Kevin Braeckmans, Wolfgang J Parak, Marek Osinski, Kenji Yamamoto
Number of pages: 1 - Focal delivery of AAV2/1-transgenes into the rat brain by localized ultrasound-induced BBB opening(2013)
Authors: Angelika Alonso, Eileen Reinz, Barbara Leuchs, Juergen Kleinschmidt, Marc Fatar, Bart Geers, Ine Lentacker, Michael G. Hennerici, Stefaan De Smedt, Stephen Meairs
- Bio-inspired surfactant-modified dextran nanogels mediate enhanced intracellular siRNA delivery(2012)Volume: 23
Authors: Lynn De Backer, Jo Demeester, Stefaan De Smedt, Koen Raemdonck
Pages: A136 - A137 - An ex vivo assay to measure the mobility inside the eye of nanomedicines for retinal gene therapy(2012)Volume: 23
Authors: Thomas Martens, Dries Vercauteren, Katrien Forier, Hendrik Deschout, Katrien Remaut, Jo Demeester, Stefaan De Smedt, Kevin Braeckmans
Pages: A81 - A82 - Evaluation of small interfering RNA delivery by nanoparticle-loaded tumoritropic cells(2012)Volume: 23
Authors: Laura Wayteck, Stefaan De Smedt, Koen Raemdonck
Pages: A71 - A71 - Investigating the toxic effects of iron oxide nanoparticles(2012)
Authors: Stefaan Soenen, Marcel De Cuyper, Stefaan De Smedt, Kevin Braeckmans, N Duzgunes
Pages: 195 - 224 - Gene and cell therapy for cystic fibrosis : from bench to bedside(2011)
Authors: Massimo Conese, Fiorentina Ascenzioni, A. Christopher Boyd, Charles Coutelle, Ida De Fino, Stefaan De Smedt, Joanna Rejman, Joseph Rosenecker, Dirk Schindelhauer, Bob J. Scholte
Pages: S114 - S128 - Pulmonary delivery of mRNA: in vitro and in vivo evaluation(2010)Volume: 15
Authors: Oliwia Andries, Joanna Rejman, Cindy Peleman, Tony Lahoutte, Stefaan De Smedt, Jo Demeester, Niek Sanders
Pages: 1080 - 1081
Patents
1 - 10 of 10
- MOLECULAR ADJUVANTS FOR ENHANCED CYTOSOLIC DELIVERY OF ACTIVE AGENTS (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)
- Composition for treatment of vitreous disease or disorder (Inventor)
- THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF (Inventor)
- Method to increase the permeability of the plasma membrane of cells and a structure suitable for use in such method (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- Composition for treatment of vitreous disease or disorder (Inventor)
- THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)