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Researcher
Dirk Daelemans
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Department of Microbiology, Immunology and Transplantation (Department)
Member
From1 Oct 2013 → 31 Oct 2013 - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 2000 → Today
Projects
1 - 10 of 29
- Optimization of the anticancer drug target deconvolution processFrom31 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Identification of proviral host factor combinations as drug targets for viruses with pandemic potentialFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Developing combinatorial immunotherapy for glioblastomaFrom7 Nov 2022 → TodayFunding: Foundations, funds and other with scientific goal
- Multiplex CRISPR screening to identify drug target combinations for antiviral therapyFrom1 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Uncovering kinase inhibitor resistance mechanisms via CRISPR-based gain-of-function mutagenesis.From12 Jul 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel class of reversible Exportin-1 inhibitors for cancer therapyFrom1 Jan 2021 → 31 Dec 2022Funding: IOF - technology validation in lab
- Identification of drug resistance mechanisms and acquired sensitivities in resistant cancer cells using genome-wide CRISPR-mediated screensFrom14 Sep 2020 → TodayFunding: FWO fellowships
- Combinatorial and personalized oncolytic virotherapy in the battle against glioblastomaFrom29 Aug 2020 → TodayFunding: FWO fellowships
- Breaking cancer drug resistance: exploring drug resistance mechanisms to exploit associated vulnerabilitiesFrom1 Jul 2020 → 30 Jun 2021Funding: BOF - postdoctoral mandates
- Intravital microscopy platform for infectious and inflammatory diseasesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
21 - 30 of 156
- Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)(2022)
Authors: Dirk Daelemans
- The search for molecular drivers of flavivirus virulence: Three-hybrid screening for sfRNA-binding host factors.(2022)
Authors: Sander Jansen, Johan Neyts, Kai Dallmeier, Dirk Daelemans
- GENERATION OF ARTIFICIAL NUCLEIC ACID SYSTEMS FOR BIOTECHNOLOGY AND THERAPEUTICS(2022)
Authors: Hui Yang, Dirk Daelemans, Elena Eremeeva
- Discovery of ( ±)-3-(1H-pyrazol-1-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazine derivatives with promising in vitro anticoronavirus and antitumoral activity(2022)
Authors: Dominique Schols, Steven De Jonghe, Dirk Daelemans
Pages: 1357 - 1371 - Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules(2022)
Authors: Thomas Vercruysse, Philip Van Damme, Dirk Daelemans, Ludo Van Den Bosch
- The T850D Phosphomimetic Mutation in the Androgen Receptor Ligand Binding Domain Enhances Recruitment at Activation Function 2(2022)
Authors: Christine Helsen, Tien Nguyen, Thomas Vercruysse, Staf Wouters, Dirk Daelemans, Arnout Voet, Frank Claessens
- Target Identification of Small Molecules Using Large-Scale CRISPR–Cas Mutagenesis Scanning of Essential Genes(2022)
Authors: Bert Kwanten, Dirk Daelemans
Pages: 43 - 67 - Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells(2021)
Authors: Rui Wang, Haibo Hu, Dirk Daelemans, Steven De Jonghe, Walter Luyten, Wim Dehaen
- Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones(2021)
Authors: Dirk Daelemans
- Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer's disease(2021)
Authors: Steven De Jonghe, Dirk Daelemans