Researcher
Frederik De Smet
- Disciplines:Macromolecular and materials chemistry, Laboratory medicine, Morphological sciences
Affiliations
- Translational Cell & Tissue Research (Division)
Member
From1 Oct 2016 → Today - Switch Laboratory (VIB-KU Leuven) (Division)
Member
From1 Jan 2011 → 30 Sep 2016 - Centre for Molecular and Vascular Biology (Division)
Member
From15 Nov 2003 → 30 Sep 2005
Projects
1 - 10 of 47
- Virtual StainingFrom15 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The malignant Glioma immuno-oncology matchmaker: towards data-driven precision medicine using spatially resolved radio-multiomicsFrom1 Jan 2024 → TodayFunding: HORIZON.2.1 - Health
- Mapping epigenetic regulatory pathways that drive Glioblastoma plasticity at single-cell resolutionFrom13 Nov 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding the RNA regulatory interactome landscape of radiation response in glioblastomaFrom13 Oct 2023 → TodayFunding: SCK (Study Centre Nuclear Energy)
- PEGASuS - PEdiatric Glioma Architecture Single cell and Spatial mapping: in search for effectors of radioresistanceFrom1 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Mapping the therapeutic potential of AG5 and its effects on TME using a multi-omics approach in IDHwt GBM patient-derived models.From1 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A platform for advanced single-cell pathological profiling of immune-brain interactionsFrom15 Jun 2023 → TodayFunding: BOF - various
- Immunotherapy for childhood, adolescent, and adult Glioblastoma: towards tumour-immune interactions driven precision medicine using spatially resolved radio-multiomics.From15 Jan 2023 → TodayFunding: BOF - various
- Targeting radiation-induced plasticity in Glioblastoma: from fundamental insights to tailored therapeutic opportunitiesFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Unique IsoPlexis technology for multiplexed single cell functional profilingFrom1 Jan 2023 → TodayFunding: BOF - scientific equipment program
Publications
41 - 50 of 67
- Targeting protein aggregation during cancer development(2019)
Authors: Evelyne Naus, Frederic Rousseau, Frederik De Smet, Joost Schymkowitz
- Linking single-cell measurements of mass, growth rate, and gene expression(2018)
Authors: Frederik De Smet
- Aggregation as a mechanism for p53 oncogenic transformation: clinical relevance and new tools for its study(2017)
Authors: Mirian Saiz Rubio, Joost Schymkowitz, Frederik De Smet, Frederic Rousseau
Number of pages: 161 - Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodeling by p53 aggregation(2017)
Authors: Frederik De Smet, Mirian Saiz Rubio, Daphne Hompes, Evelyne Naus, Tobias Langenberg, Bert Houben, Filip Claes, Stéphane Plaisance, Frédéric Amant, Xavier Sagaert, et al.
Pages: 24 - 38 - FGF-dependent metabolic control of vascular development(2017)
Authors: Frederik De Smet, Peter Carmeliet
Pages: 224 - 228 - Therapeutic Potential of Allosteric Modulation of FGF Receptors(2017)
Authors: Frederik De Smet, Peter Carmeliet
Pages: 169 - 185 - De novo design of a biologically active amyloid(2016)
Authors: Rodrigo Gallardo, Frederik De Smet, Filip Claes, Laleh Khodaparast, Ladan Khodaparast, Tobias Langenberg, Maxime Siemons, Manoj Kumar Gautam, Manu Beerens, Aernout Luttun, et al.
- Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling (vol 23, pg 489, 2013)(2016)
Authors: Corentin Herbert, Ulrich Schieborr, Krishna Saxena, Jarek Juraszek, Frederik De Smet, Chantal Alcouffe, Marc Bianciotto, Giorgio Saladino, David Sibrac, Denis Kudlinzki, et al.
Pages: 176 - 178 - Sequence-specific protein aggregation generates defined protein knockdowns in plants(2016)
Authors: Rodrigo Gallardo, Frederik De Smet, Frederic Rousseau, Joost Schymkowitz
Pages: 773 - 787 - Structural hot spots for the solubility of globular proteins(2016)
Authors: Aleksandra Siekierska, Joost Van Durme, Greet De Baets, Rob van der Kant, Rodrigo Gallardo, Tobias Langenberg, Frederik De Smet, Chris Ulens, Frederic Rousseau, Joost Schymkowitz
Pages: 10816 - 10816
Patents
1 - 5 of 5
- Means and methods for generating improved proteins (Inventor)
- Means and methods for generating improved proteins (Inventor)
- Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor (Inventor)
- Methods for screening inhibitors of tumor associated protein aggregation (Inventor)
- Methods for screening inhibitors of tumour associated protein aggregation. (Inventor)