Researcher
Kris Vleminckx
- Keywords:cancer research, rare diseases, CRISPR/Cas9, Developmental biology
- Disciplines:Cell signalling, Developmental genetics, Genome structure and regulation, Developmental biology, Vertebrate biology, Epigenetics, Genetics, Animal developmental and reproductive biology, Cancer biology
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Jan 2013 → 30 Sep 2018 - Department of Biomedical molecular biology (Department)
Member
From1 Jan 1999 → Today
Projects
1 - 10 of 30
- Morphological, molecular and functional insights into the cardiovascular complications of autosomal dominant polycystic kidney diseaseFrom1 Nov 2023 → TodayFunding: BOF - postdoctoral mandates
- Interspecies exploration of the (post)transcriptional and epigenomic signatures associated with Wilms' tumor formationFrom1 Nov 2023 → TodayFunding: FWO fellowships
- CRISPR-mediated mapping of genetic dependencies in well-differentiated and dedifferenciated liposarcomaFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Pathomechanistic study of RCBTB1-associated inherited retinal disease using Xenopus tropicalis and patient-derived induced pluripotent stem cellsFrom1 Oct 2022 → 31 Oct 2023Funding: BOF - doctoral mandates
- Functional assessment of cis-regulatory elements of inherited retinal diseases (IRDs) in Xenopus tropicalisFrom1 May 2022 → 30 Apr 2023Funding: BOF - doctoral mandates
- Investigating the role and mechanism of EZH2 in immune checkpoint resistance in tumors with Wnt/ß-catenin pathway activationFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Identification et caractérisation des facteurs de dépendance dans un modèle génétique de tumeur desmoïde de Xenopus tropicalisFrom1 Sep 2020 → 31 Aug 2022Funding: Other international institutions, not mentioned elsewhere
- Precision medicine in inherited blindness using integrated omics in human and animal modelsFrom1 Jan 2020 → TodayFunding: BOF - projects
- Identifying and characterizing dependency factors in a genetic Xenopus tropicalis desmoid tumor modelFrom15 Jul 2019 → 14 Jul 2021Funding: Foreign foundations, funds with scientific view
- CRISPR/Cas9-based in vivo identification of EZH2 as a therapeutic target in desmoid tumors and small cell lung cancerFrom1 Jan 2019 → 31 Dec 2019Funding: Foundations, funds and other with scientific goal
Publications
21 - 30 of 62
- TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis(2015)
Authors: Tom Van Nieuwenhuysen, Thomas Naert, Hong Tran Thi, Griet Van Imschoot, Sarah Geurs, Ellen Sanders, David Creytens, Frans Van Roy, Kris Vleminckx
Pages: 555 - 566 - Genetic defects in TAPT1 disrupt ciliogenesis and cause a complex lethal osteochondrodysplasia(2015)
Authors: Aileen M Barnes, Charlotte Gistelinck, Fransiska Malfait, Brecht Guillemyn, Wouter Steyaert, Sanne D'hondt, Martine Biervliet, Paul Witten, Sergey Leikin, Elena Makareeva, et al.
Pages: 521 - 534 - SF3B2, a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein(2015)Volume: 56
Authors: Caroline Van Cauwenbergh, Kris Vleminckx, Frauke Coppieters, Marcus Karlstetter, Thomas Langmann, Gael Manes, Christian P Hamel, Bart Leroy, Elfride De Baere
Number of pages: 1 - A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes(2015)
Authors: Philippe De Groote, Hong Tran Thi, Mathias Fransen, Giel Tanghe, Corinne Urwyler, Bram De Craene, Kirsten Leurs, Barbara Gilbert, Griet Van Imschoot, Chris Guerin, et al.
Pages: 1012 - 1024 - SF3B2, a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein(2015)Volume: 23
Authors: Caroline Van Cauwenbergh, Marcus Karlstetter, Kris Vleminckx, Gael Manes, Thomas Langmann, Christian Hamel, Bart Leroy, Frauke Coppieters, Elfride De Baere
Pages: 73 - 73 - TALEN mediated mutation of apc and β-catenin in Xenopus tropicalis as powerful models for Wnt driven cancer and Familial Adenomatous Polyposis (FAP)(2015)Volume: 75
Authors: Tom Van Nieuwenhuysen, Thomas Naert, David Creytens, Frans Van Roy, Kris Vleminckx
Number of pages: 1 - Defects in TAPT1, involved in axial skeletal patterning, cause a complex lethal recessive disorder of skeletal development(2014)
Authors: Aileen Barnes, Charlotte Gistelinck, Fransiska Malfait, Kris Vleminckx, Brecht Guillemyn, Wouter Steyaert, Eef Parthoens, Martine Biervliet, Gabriele Gillessen-Kaesbach, Hans Peter Bächinger, et al.
Number of pages: 1 - Transcription factor Zic2 inhibits Wnt/U+03B2-catenin protein signaling(2011)
Authors: Rasoul Pourebrahim, Rob Houtmeyers, Stephen Ghogomu, Sylvie Janssens, Aurore Thelie, Hong Tran Thi, Tobias Langenberg, Kris Vleminckx, Eric Bellefroid, Jean-Jacques Cassiman, et al.
Pages: 37732 - 37740 - ARVCF Depletion cooperates with Tbx1 deficiency in the development of 22q11.2DS-like phenotypes in Xenopus(2011)
Authors: Hong Tran Thi, Mieke Delvaeye, Veerle Verschuere, Emilie Descamps, Ellen Crabbe, Pierre McCrea, Frans Van Roy, Kris Vleminckx
Pages: 2680 - 2687 - Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development(2010)
Authors: Nicolas Willemarck, Evelien Rysman, Koen Brusselmans, Griet Van Imschoot, Frank Vanderhoydonc, Katrien Moerloose, Evelyne Lerut, Guido Verhoeven, Frans Van Roy, Kris Vleminckx, et al.
Pages: 9453 - 9462