Researcher
Kris Vleminckx
- Keywords:cancer research, rare diseases, CRISPR/Cas9, Developmental biology
- Disciplines:Cell signalling, Developmental genetics, Genome structure and regulation, Developmental biology, Vertebrate biology, Epigenetics, Genetics, Animal developmental and reproductive biology, Cancer biology
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Jan 2013 → 30 Sep 2018 - Department of Biomedical molecular biology (Department)
Member
From1 Jan 1999 → Today
Projects
1 - 10 of 30
- Morphological, molecular and functional insights into the cardiovascular complications of autosomal dominant polycystic kidney diseaseFrom1 Nov 2023 → TodayFunding: BOF - postdoctoral mandates
- Interspecies exploration of the (post)transcriptional and epigenomic signatures associated with Wilms' tumor formationFrom1 Nov 2023 → TodayFunding: FWO fellowships
- CRISPR-mediated mapping of genetic dependencies in well-differentiated and dedifferenciated liposarcomaFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Pathomechanistic study of RCBTB1-associated inherited retinal disease using Xenopus tropicalis and patient-derived induced pluripotent stem cellsFrom1 Oct 2022 → 31 Oct 2023Funding: BOF - doctoral mandates
- Functional assessment of cis-regulatory elements of inherited retinal diseases (IRDs) in Xenopus tropicalisFrom1 May 2022 → 30 Apr 2023Funding: BOF - doctoral mandates
- Investigating the role and mechanism of EZH2 in immune checkpoint resistance in tumors with Wnt/ß-catenin pathway activationFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Identification et caractérisation des facteurs de dépendance dans un modèle génétique de tumeur desmoïde de Xenopus tropicalisFrom1 Sep 2020 → 31 Aug 2022Funding: Other international institutions, not mentioned elsewhere
- Precision medicine in inherited blindness using integrated omics in human and animal modelsFrom1 Jan 2020 → TodayFunding: BOF - projects
- Identifying and characterizing dependency factors in a genetic Xenopus tropicalis desmoid tumor modelFrom15 Jul 2019 → 14 Jul 2021Funding: Foreign foundations, funds with scientific view
- CRISPR/Cas9-based in vivo identification of EZH2 as a therapeutic target in desmoid tumors and small cell lung cancerFrom1 Jan 2019 → 31 Dec 2019Funding: Foundations, funds and other with scientific goal
Publications
11 - 20 of 62
- Cancer models in Xenopus tropicalis by CRISPR/Cas9 mediated knockout of tumor suppressors(2018)Series: Methods in Molecular Biology
Authors: Thomas Naert, Kris Vleminckx
Pages: 147 - 161 - Genotyping of CRISPR/Cas9 genome edited Xenopus tropicalis(2018)Series: Methods in Molecular Biology
Authors: Thomas Naert, Kris Vleminckx
Pages: 67 - 82 - Cell cycle analysis of the embryonic brain of fluorescent reporter Xenopus tropicalis by flow cytometry(2018)Series: Methods in Molecular Biology
Authors: Rivka Noelanders, Kris Vleminckx
Pages: 243 - 250 - BATCH-GE : analysis of NGS data for genome editing assessment(2018)Series: Methods in Molecular Biology
Authors: Wouter Steyaert, Annekatrien Boel, Paul Coucke, Andy Willaert, Kris Vleminckx
Pages: 83 - 90 - Targeted genome engineering in Xenopus using the transcription activator-like effector nuclease (TALEN) technology(2018)Series: Methods in Molecular Biology
Authors: Tom Van Nieuwenhuysen, Kris Vleminckx
Pages: 55 - 65 - Methods for CRISPR/Cas9 Xenopus tropicalis tissue-specific multiplex genome engineering(2018)Series: Methods in Molecular Biology
Authors: Thomas Naert, Kris Vleminckx
Pages: 33 - 54 - RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6(2018)
Authors: Emmanuelle Szenker-Ravi, Umut Altunoglu, Marc Leushacke, Celia Boss-Lefevre, Muznah Khatoo, Hong Tran Thi, Thomas Naert, Rivka Noelanders, Amin Hajamohideen, Claire Beneteau, et al.
Pages: 564 - 569 - Caspase-9 has a nonapoptotic function in Xenopus embryonic primitive blood formation(2017)
Authors: Hong Tran Thi, Mathias Fransen, Dionysia Dimitrakopoulou, Griet Van Imschoot, Nicolas Willemarck, Kris Vleminckx
Pages: 2371 - 2381 - How Wnt signaling builds the brain : bridging development and disease(2017)
Authors: Rivka Noelanders, Kris Vleminckx
Pages: 314 - 329 - CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis(2016)
Authors: Thomas Naert, Tom Van Nieuwenhuysen, Dionysia Dimitrakopoulou, Jannick Leoen, Jurgen Haustraete, Wouter Steyaert, Trees Lepez, Dieter Deforce, Kris Vleminckx